Directed Actin Assembly and Contractility
نویسندگان
چکیده
منابع مشابه
Geometrical Control of Actin Assembly and Contractility 2
The actin cytoskeleton is a fundamental player in many cellular processes. Ultrastructural studies have revealed its extremely complex organization, where actin filaments self-organize into defined and specialized structures of distinct functions and, yet, are able to selectively recruit biochemical regulators that are available in the Methods in Cell Biology, Volume 120 ISSN 0091-679X Copyrigh...
متن کاملArchitecture and Connectivity Govern Actin Network Contractility
Actomyosin contractility plays a central role in a wide range of cellular processes, including the establishment of cell polarity, cell migration, tissue integrity, and morphogenesis during development. The contractile response is variable and depends on actomyosin network architecture and biochemical composition. To determine how this coupling regulates actomyosin-driven contraction, we used a...
متن کاملTension-Sensitive Actin Assembly Supports Contractility at the Epithelial Zonula Adherens
BACKGROUND Actomyosin-based contractility acts on cadherin junctions to support tissue integrity and morphogenesis. The actomyosin apparatus of the epithelial zonula adherens (ZA) is built by coordinating junctional actin assembly with Myosin II activation. However, the physical interaction between Myosin and actin filaments that is necessary for contractility can induce actin filament turnover...
متن کاملContractility-dependent actin dynamics in cardiomyocyte sarcomeres.
In contrast to the highly dynamic actin cytoskeleton in non-muscle cells, actin filaments in muscle sarcomeres are thought to be relatively stable and undergo dynamics only at their ends. However, many proteins that promote rapid actin dynamics are also expressed in striated muscles. We show that a subset of actin filaments in cardiomyocyte sarcomeres displays rapid turnover. Importantly, we fo...
متن کاملFibroblast contractility and actin organization are stimulated by microtubule inhibitors.
Despite considerable evidence that cytoplasmic microtubules play some role in guiding or controlling the locomotion of tissue cells, the nature of this control is not understood. In particular, little is known about the role of microtubules in the exertion of propulsive 'traction' forces, or about microtubule effects on the organization of the cytoplasmic actin stress fibers. In this study, the...
متن کاملذخیره در منابع من
با ذخیره ی این منبع در منابع من، دسترسی به آن را برای استفاده های بعدی آسان تر کنید
ژورنال
عنوان ژورنال: Biophysical Journal
سال: 2014
ISSN: 0006-3495
DOI: 10.1016/j.bpj.2013.11.3461